|
KMID : 0381219860180020140
|
|
Journal of RIMSK
1986 Volume.18 No. 2 p.140 ~ p.146
|
|
|
STI Changes between Thiopental Sodium and Etomidate
|
|
|
|
|
Abstract
|
|
|
Thiopental sodium has been the most commonly used induction agent of anesthesia. It has been well known that thiopental sodium causes histamine release and cardiac depression, therefore, it is not suitable for the anesthesia of patient who has cardiovascular diseases.
In 1971, etomidate was introduced as a new nonbarbiturate hypnotic agent by Janssen Pharmaceutical and it has the advantages of lesser histamine release, minimal effects on the cardiovascular and pulmonary system. So we tried to compare the cardiovascular effects of these two drugs by STI measurement in 51 subjects estimated as ASA class 1 or 2. We measure the blood pressure and STIs in the resting state and after injection of thiopental sodium or etomidate for 10 min.
The results were as follows;
1) There is a significant increase in PEP, PEP/LVET ratio and decrease in MAP, 1/PEPZ ratio in the thiopental group. (p<0. 01)
2) There are no significant changes of MAP and STIs in the etomidate group.
So we concluded that etomidate has lesser depressive effects on the cardiovascular system than thiopental, therefore, it is more effective induction agent in the anesthesia of patients who have cardiovascular disease.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|